Isabel Stötzel

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

This study develops a fluorescent ligand to identify improved antagonists targeting the intracellular allosteric site of CCR7, showing their effectiveness in both recombinant and endogenous settings.