Author

Vargab Baruah

Cleveland ClinicORCID 0000-0002-2882-7785Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Christine M. O’ConnoriD· 5 shared Benjamin A. KrishnaiD· 2 shared Ian J. GrovesiD· 2 shared Aarav Badani· 1 shared Abigail L. DooleyiD· 1 shared Alex Vincenti· 1 shared Alliefair ScaliseiD· 1 shared Alok A. KhoranaiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersMicrobiology

Christine M. O’ConnorORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Platelets regulate glioblastoma growth and immunity via sex-dependent PAR4 - Estrogen receptor beta signaling

Anthony R. Sloan, George Bukenya, Gavin P. Tannish, Daniel J. Silver, Anu Aggarwal, Juyeun Lee, Daniel Rosoff, Tyler J. Alban, Ivan Juric, Shikha Parsai, Vargab Baruah, Tyler Bodovetz, Donovan Whitfield, Liza Tack, Tanvi Navadgi, , Justin Durla Lathia

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

Cancer Cell · Oct 1, 2026Peer-reviewedCancer Biology

The Human Cytomegalovirus vGPCR UL33 is Essential for Efficient Lytic Replication in Epithelial Cells

MacKenzie R. Freeman, Abigail L. Dooley, Ian J. Groves, Jay Wright, Matthew J. Beucler, Vargab Baruah, Xu Qi, Wes Sanders, Nathaniel J. Moorman, Christine M. O’Connor, William E. Miller

This study shows that deletion of UL33 from HCMV genome reduces lytic replication in epithelial cells by impairing Gq-dependent signaling and gene expression.

Journal of Virology · Aug 31, 2026Peer-reviewedMicrobiology

The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infection

Vargab Baruah, Christine M. O’Connor

This paper identifies the activation of the BTK-DDX41-STING signaling pathway during CMV lytic infection and shows how the virus subverts this pathway by reducing DDX41 activity.

Journal of Virology · Sep 16, 2025Peer-reviewedMicrobiology

Human cytomegalovirus-encoded G protein-coupled receptor (GPCR), UL78, regulates viral reactivation

Samuel Ayodeji Osanyinlusi, Vargab Baruah, Ian J. Groves, Katherine H. Kulp, Benjamin A. Krishna, Christine M. O’Connor

This study identifies UL78 as a viral factor that facilitates the switch from latency to reactivation in CMV-infected myeloid cells by modulating cellular signaling.

Journal of Virology · Aug 27, 2025Peer-reviewedMicrobiology

Inhibition of MAPK signaling suppresses cytomegalovirus reactivation in CD34+ Kasumi-3 cells

Vargab Baruah, Benjamin A. Krishna, Michael C. Kelly, Qi Xu, Christine M. O'Connor

This study shows that inhibiting MAPK signaling suppresses CMV reactivation in CD34+ Kasumi-3 cells, suggesting a therapeutic target for preventing viral reactivation in immunocompromised patients.

Antiviral Research · Apr 16, 2025Peer-reviewedMicrobiology