Author

Steven D. Cappell

National Institutes of HealthORCID 0000-0002-2885-7327Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Amy E. JamesiD· 1 shared Amy L. FunkiD· 1 shared Amy L. Ries· 1 shared Andy D. TraniD· 1 shared Anna A. MarusiakiD· 1 shared Baktiar O. KarimiD· 1 shared Bechara SaykaliiD· 1 shared Carolyn C. WoodroofeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Amy E. JamesORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Lineage-specific CDK activity dynamics characterize early mammalian development

Bechara Saykali, Andy D. Tran, James A. Cornwell, Matthew A. Caldwell, Paniz Rezvan Sangsari, Nicole Y. Morgan, Michael J. Kruhlak, Steven D. Cappell, Sergio Ruiz

The paper quantifies CDK activity in mouse embryos and shows it decreases in trophectoderm cells before implantation, correlating with FGF4 signaling, but does not determine cell fate.

Cell Reports · Apr 1, 2025Peer-reviewedDevelopmental Biology

Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth

Amy L. Funk, Meghri Katerji, Marwa M. Afifi, Katherine M. Nyswaner, Carolyn C. Woodroofe, Zoe C. Edwards, Eric Lindberg, Knickole L. Bergman, Nancy R. Gough, Maxine R. Rubin, Kamila Karpińska, Eleanor W. Trotter, Sweta Dash, Amy L. Ries, Amy E. James, , John Brognard

This study identifies LZK as a therapeutic target in HNSCC by showing its regulation of c-MYC and GOF p53, and demonstrates PROTAC-mediated degradation as a potential treatment.

Science Signaling · Feb 11, 2025Peer-reviewedCancer Biology

Steven D. Cappell · henhao