Author

Brian Guy

Johns Hopkins UniversityORCID 0000-0002-2891-6585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Clayton P. SantiagoiD· 2 shared Robert J. JohnstoniD· 2 shared Seth BlackshawiD· 2 shared Caterina TiozzoiD· 1 shared Ian A. GlassiD· 1 shared Jingliang Simon ZhangiD· 1 shared Katarzyna A. HusseyiD· 1 shared Kiara C. EldrediD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Clayton P. SantiagoORCID

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2 papers

Recent·Most cited

Developmental BiologyCell ReportsPeer-reviewedApr 1, 2026

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Jingliang Simon Zhang, Brian Guy, Clayton P. Santiago…·Robert J. Johnston

This study shows that blocking apoptosis in retinal organoids increases RGC survival but delays their development, highlighting apoptosis's role in regulating RGC quantity and dynamics.

DOI 10.1016/j.celrep.2026.117270

humanspatial transcriptomics

𝕏 PostBluesky

Developmental BiologybioRxivPreprintJan 28, 2023

Cell fate specification and conversion generate foveolar cone subtype patterning in human retinal organoids

Katarzyna A. Hussey, Kiara C. Eldred, Brian Guy…·Robert J. Johnston

The paper identifies mechanisms that generate M/L cone dominance and suppress S cones in the human foveola using retinal organoids and signaling pathway regulators.

4 citations

humanscRNA-seq

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