Kiara C. Eldred

DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids

This study identifies DIO3 as a regulator of photoreceptor development timing and fate stability in human retinal organoids, proposing an hourglass model for developmental progression.

CUT&TIME captures the history of open chromatin indeveloping neurons

The paper introduces CUT&TIME, a method to map historical chromatin accessibility in single cells during neurogenesis, revealing early changes in promoter accessibility linked to cell-fate commitment in retinal ganglion cells.

Ciliary marginal zone of the developing human retina maintains retinal progenitor cells until late gestational stages

The paper identifies a proliferative region in the fetal human retina that continues to generate neurons late in development, similar to the non-mammalian ciliary marginal zone.

Synchronized long-read genome, methylome, epigenome, and transcriptome for resolving a Mendelian condition

Pooling Fiber-seq gDNA with concatenated MAS-Seq cDNA in one PacBio run gives phased genome, methylome, chromatin, and transcriptome, exposing four gene disruptions from one X;13 translocation.

Developmental adaptation of rod photoreceptor number via photoreception in melanopsin (OPN4) retinal ganglion cells

The paper identifies a retinal signaling pathway where melanopsin-expressing retinal ganglion cells regulate rod photoreceptor number during development through light-dependent communication.

Single-cell sequencing of individual retinal organoids reveals determinants of cell fate heterogeneity

The paper uses sci-Plex to analyze retinal organoids and identifies that early Wnt signaling increases retinal cell classes.

Cell fate specification and conversion generate foveolar cone subtype patterning in human retinal organoids

The paper identifies mechanisms that generate M/L cone dominance and suppress S cones in the human foveola using retinal organoids and signaling pathway regulators.

Spatiotemporal specification of human green and red cones

The paper investigates the spatiotemporal development of M and L cones in the human retina, finding that retinoic acid signaling promotes M cone fate early in development.

Modeling binary and graded cone cell fate patterning in the mouse retina

The paper develops a stochastic model of cone cell fate patterning in the mouse retina based on thyroid hormone signaling and single-cell opsin expression data.

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

The paper shows thyroid hormone signaling controls the temporal switch between S and L/M cone fates in human retinal organoids.