Author

Nikolas Capra

Oak Ridge National LaboratoryORCID 0000-0002-2898-6479Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Dana L. CarperiD· 3 shared John F. CahilliD· 3 shared Joshua K. MicheneriD· 3 shared Célestin BourgeryiD· 2 shared Flora MeilleuriD· 2 shared Isaiah T. DishneriD· 2 shared Jeffrey C. FosteriD· 2 shared Jerry M. ParksiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Dana L. CarperORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural and oligomeric characterization of substrate- and product-selective nylon hydrolases

Nikolas Capra, Célestin Bourgery, Jerry M. Parks, Dana L. Carper, John F. Cahill, Joshua K. Michener, Flora Meilleur

This study characterizes three nylon hydrolases, identifying structural features and activity differences that inform their substrate specificity and potential for engineering.

bioRxiv · Mar 19, 2026 · PreprintBiochemistry

Regioselective biosynthesis of oligoamides as precursors for sequence-controlled co-polyamides

Liangyu Qian, Isaiah T. Dishner, Nikolas Capra, Dana L. Carper, Nduka D. Ogbonna, Vilmos Kertész, John F. Cahill, Jeffrey C. Foster, Joshua K. Michener

This study demonstrates that NIS synthetases can synthesize sequenced oligoamides from unprotected substrates, enabling the creation of novel sequence-defined polyamides with improved properties.

bioRxiv · Nov 3, 2025 · PreprintBiochemistry

Identification and characterization of substrate- and product-selective nylon hydrolases

Erin E. Drufva, John F. Cahill, Patricia M. B. Saint‐Vincent, Alexis N. Williams, Vera Bocharova, Nikolas Capra, Flora Meilleur, Dana L. Carper, Célestin Bourgery, Kaito Miyazaki, Maina Yonemura, Yuki Shiraishi, Jerry M. Parks, Muchu Zhou, Isaiah T. Dishner, , Joshua K. Michener

The paper identifies and characterizes diverse nylon hydrolases, showing that 40% of tested enzymes have significant activity, with some showing substrate selectivity for Nylon 6,6 over Nylon 6.

Chem Catalysis · Jun 13, 2025Peer-reviewedBiochemistry