Author

Isaiah T. Dishner

Oak Ridge National LaboratoryORCID 0000-0002-7333-9182Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Dana L. CarperiD· 3 shared Jeffrey C. FosteriD· 3 shared John F. CahilliD· 3 shared Joshua K. MicheneriD· 3 shared Vilmos KertésziD· 3 shared Jerry M. ParksiD· 2 shared Liangyu QianiD· 2 shared Nduka D. OgbonnaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBiochemistry

Dana L. CarperORCID

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3 papers

Recent·Most cited

Improved nylon polymerization using amide diads

Liangyu Qian, Isaiah T. Dishner, Dana L. Carper, Jerry M. Parks, Vilmos Kertész, Nicholas T Zolnierczuk, Nduka D. Ogbonna, Nikki A. Thiele, John F. Cahill, Jeffrey C. Foster, Joshua K. Michener

This paper demonstrates a method to produce higher-molecular-weight nylons using chemically-synthesized diads and biosynthetic amide synthetases, expanding the range of usable precursors.

Green Chemistry · Jan 1, 2026Peer-reviewedBiochemistry

Regioselective biosynthesis of oligoamides as precursors for sequence-controlled co-polyamides

Liangyu Qian, Isaiah T. Dishner, Nikolas Capra, Dana L. Carper, Nduka D. Ogbonna, Vilmos Kertész, John F. Cahill, Jeffrey C. Foster, Joshua K. Michener

This study demonstrates that NIS synthetases can synthesize sequenced oligoamides from unprotected substrates, enabling the creation of novel sequence-defined polyamides with improved properties.

bioRxiv · Nov 3, 2025 · PreprintBiochemistry

Identification and characterization of substrate- and product-selective nylon hydrolases

Erin E. Drufva, John F. Cahill, Patricia M. B. Saint‐Vincent, Alexis N. Williams, Vera Bocharova, Nikolas Capra, Flora Meilleur, Dana L. Carper, Célestin Bourgery, Kaito Miyazaki, Maina Yonemura, Yuki Shiraishi, Jerry M. Parks, Muchu Zhou, Isaiah T. Dishner, , Joshua K. Michener

The paper identifies and characterizes diverse nylon hydrolases, showing that 40% of tested enzymes have significant activity, with some showing substrate selectivity for Nylon 6,6 over Nylon 6.

Chem Catalysis · Jun 13, 2025Peer-reviewedBiochemistry