Author

Nelson O. Gekara

University of FreiburgORCID 0000-0002-1269-8288Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Amitha KamathiD· 1 shared Anetta HärtlováiD· 1 shared Anneli StrömbergiD· 1 shared Caitlyn MyersiD· 1 shared Daniela FabrikováiD· 1 shared Gesine PauliD· 1 shared Ivana MarićiD· 1 shared Ivo FabrikiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Amitha KamathORCID

Author profile →

2 papers

Recent·Most cited

Aging-associated endo-lysosomal dysfunction drives inflammaging and neurodegeneration through the STING-IFN-I axis

Maria Öberg, Ivana Marić, Anneli Strömberg, Caitlyn Myers, Najmeh Saffarzadeh, Daniela Fabriková, Ivo Fabrik, Laia Rivas-Galvez, Karolina Patrycja Skibicka, Marzena Kurzawa‐Akanbi, Gesine Paul, Nelson O. Gekara, Anetta Härtlová

This study shows that LRRK2 gain of function accelerates aging by causing endo-lysosomal dysfunction, leading to inflammation and neurodegeneration via the STING-IFN-I axis.

bioRxiv · Mar 18, 2026 · PreprintImmunology

K27-linked ubiquitination restrains the NOD2-RIP2 signaling pathway

Swarupa Panda, Amitha Kamath, Nelson O. Gekara

This study identifies K27-linked ubiquitination of RIP2 by XIAP as an inhibitory signal that modulates NOD2-RIP2 signaling and cytokine production.

bioRxiv · Jan 20, 2026 · PreprintImmunology