Selective cross-TAD gene regulation by the Tcra enhancer during T cell development
Alonso Rodríguez-Caparrós, Laura López-Castellanos, Jennifer López-Ros, Víctor Castro-Ruiz, María Duarte-Ruiz, Sandra Jiménez-Lozano, Adela Moreno-Castillo, Laura Carmen Terron-Camero, Eduardo Andrés‐León, Carlos Suñé, Cristina Hernández-Munaín
The paper shows a Tcra enhancer can regulate a distal gene in a different TAD during T-cell development, challenging the idea that TAD boundaries block enhancer-promoter interactions.
bioRxiv · May 1, 2026 · PreprintGenomics