Cristina Moreno‐Castro

TRMT10A deficiency and tRNA fragmentation disrupt human pancreatic β-cell identity and insulin maturation

This study shows TRMT10A deficiency causes β-cell dysfunction by promoting tRNA fragmentation and disrupting PCSK1 expression, leading to impaired insulin maturation and glucose-stimulated insulin secretion.

Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity

This study identifies PRPF40B as a regulator of NTRK2 alternative splicing, influencing TRKB isoform production and impacting neuronal differentiation and synaptic plasticity.

The type 1 diabetes-associated lncRNA ARGI participates in virus-induced pancreatic beta cell inflammation.

This study identifies the lncRNA ARGI as a mediator of virus-induced inflammation in pancreatic beta cells linked to type 1 diabetes through allele-specific transcriptional activation.