Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms
Mohammad Alfatah, Jolyn Jia Jia Lim, Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng, Sonia Yogasundaram, Nashrul Afiq Faidzinn, Jovian Jing Lin, Birgit Eisenhaber, Frank Eisenhaber
This study identifies YBR238C as a regulator of cellular aging in yeast, showing it modulates mitochondrial function through HAP4 and RMD9, and links TORC1 activity to mitochondrial feedback loops affecting aging.
eLife · Nov 24, 2023Peer-reviewedGenetics