Nashrul Afiq Faidzinn

The paper identifies metabolic state transitions regulated by TORC1 that influence cellular aging in yeast and human cells.

This study shows mitochondrial competence determines cellular responses to metabolic interventions during aging, with TORC1 signaling and mitochondrial function being key factors.

This study identifies YBR238C as a regulator of cellular aging in yeast, showing it modulates mitochondrial function through HAP4 and RMD9, and links TORC1 activity to mitochondrial feedback loops affecting aging.

This study shows curcumin extends the lifespan of aging postmitotic yeast cells with mitochondrial dysfunction, but not under conditions of mitochondrial dysfunction.

This study identifies hemin as an anti-aging agent that extends cellular lifespan through the AMPK pathway and synergizes with rapamycin in human and yeast models.