Chengqi Yi

This study identifies m3C as a novel mitochondrial mRNA modification catalyzed by METTL8, which promotes tumor progression by enhancing complex I activity and oncogenic pathways.

MethylQUEEN is a DNA methylation foundation model that captures epigenetic information and enables tissue-of-origin tracing and disease detection through methylation patterns.

The paper develops a method to quantitatively profile pseudouridylation sites in the human transcriptome and identifies modification targets of pseudouridine synthases.

The study reveals that m6A RNA methylation stabilizes maternal RNAs in mouse oocytes and promotes the degradation of 2-cell specific RNAs during early embryonic development.

This paper introduces ATRAC-seq, a method using Tn5 transposase to tagment RNA/DNA hybrids for RNA sequencing, offering a faster and simpler library construction protocol.

The paper profiles m6A and m6Am methylomes across 42 human and 16 mouse tissues, revealing tissue-specific patterns and cross-species conservation.