Author

Ruijie Gong

Fudan UniversityORCID 0000-0002-6006-8547Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Jia FaniD· 2 shared Qin Feng· 2 shared Songchen Liu· 2 shared Xianjiang LaniD· 2 shared Yijie SheniD· 2 shared Chuxuan Peng· 1 shared Fei LaniD· 1 shared Jia Yu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Jia FanORCID

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2 papers

Recent·Most cited

Cell BiologyOncogenePeer-reviewedMar 30, 2026

Dual function of DOT1L suppresses tumor intrinsic immunogenicity in hepatocellular carcinoma

Siyuan Xu, Ruijie Gong, Songchen Liu…·Xianjiang Lan

The paper identifies DOT1L as a suppressor of tumor intrinsic immunogenicity using CRISPR screens and shows its inhibition enhances immune response in mice.

DOI 10.1038/s41388-026-03744-6

mousehuman

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJan 23, 2026

BRD8 Disruption Unlocks Retrotransposon-Driven Tumor-Intrinsic Immunogenicity via Redistribution of Histone Acetylation in Liver Cancer

Ruijie Gong, Yijie Shen, Jianhang Huang…·Xianjiang Lan

This study identifies BRD8 as an epigenetic suppressor of tumor-intrinsic immunity in liver cancer, showing its depletion enhances immunogenicity and sensitizes tumors to immunotherapy.

DOI 10.64898/2026.01.21.700714

mousehuman

𝕏 PostBluesky