David S. Jones

Maternal immune gene expression trajectories and dynamic genetic regulation throughout pregnancy

This study tracks maternal immune gene expression and genetic regulation throughout pregnancy, revealing dynamic changes and genetic interactions linked to pregnancy complications.

The human placenta exhibits a unique transcriptomic void

The paper identifies 762 transcripts uniquely depleted in the placenta compared to 46 other human organs, highlighting mitochondrial and polyamine metabolism enrichment.

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

Somatic mutations reveal widespread mosaicism and mutagenesis in human placentas

This study uses whole genome sequencing of placental biopsies to show that human placentas exhibit clonal expansions, copy number changes, and developmental bottlenecks similar to childhood cancer.

Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice

The paper uses single-cell RNA sequencing to identify thymic maturation delay in growth-restricted neonatal mice, showing reduced T-cellularity and altered cell cycle regulation.