The DJ-1-derived peptide, ND-13, confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1 pathway
Aishwarya Prakash, Gustavo E Crespo-Avilan, Sze Jie Loo, En Ping Yap, Jasper Chua, Jianhong Ching, Zeng Yitong, Ying‐Hsi Lin, Whendy Contreras, Fan Yu, Shuo Cong, Linh Chi Dam, Chrishan J. A. Ramachandra, Siavash Beikoghli Kalkhoran, Shengjie Lu, , Derek John Hausenloy
This study shows that the DJ-1-derived peptide ND-13 reduces myocardial infarct size and preserves cardiac function by inhibiting mitochondrial fission and improving mitochondrial bioenergetics through the RhoA-ROCK1-Drp1 pathway.
bioRxiv · Jun 24, 2024 · PreprintPhysiology