Jianhong Ching

This paper identifies causal genes in diabetic nephropathy using a cross-species systems genetics framework, finding 192 candidate genes with 40% validated in humans.

This study shows that the DJ-1-derived peptide ND-13 reduces myocardial infarct size and preserves cardiac function by inhibiting mitochondrial fission and improving mitochondrial bioenergetics through the RhoA-ROCK1-Drp1 pathway.

This study identifies metabolic dysfunction, particularly in the TCA cycle, as an early and causative event in Alzheimer's disease using a transgenic C. elegans model.