Paul J. Harrison

The paper assesses mood instability and circadian patterns in individuals at risk for bipolar disorder using digital monitoring and actigraphy over 10 weeks.

This study shows that GluA1 dysfunction leads to impaired short-term habituation, resulting in a hyper-dopaminergic phenotype in the nucleus accumbens, which may contribute to aberrant salience in schizophrenia.

This study uses nanopore direct RNA sequencing to accurately detect differential gene and isoform expression between human cell populations during differentiation.

The paper uses long-read sequencing to uncover the complex splicing profile of the CACNA1C gene in human brain, identifying numerous novel exons and transcripts with potential functional implications.

This paper conducts a GWAS of mood instability in 363,705 UK Biobank participants, identifies 46 loci, and finds genetic correlations with psychiatric disorders and brain-specific gene expression.

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.