Shia Vang

O-GlcNAc transferase regulates H2O2 production via p38 MAPK

This paper shows that OGT inhibition reduces TGF-β-induced p38 MAPK signaling and H2O2 production in lung fibroblasts through O-GlcNAcylation of p38 and p47phox.

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

CD248 activates TGF-β receptor I to promote vascular remodeling in pulmonary arterial hypertension

This study identifies CD248 as a co-activator of TGF-β receptor I in pulmonary arterial hypertension, supporting anti-CD248 therapy as a targeted alternative to systemic TGF-β inhibition.