Author

Kenneth P. Hough

University of Alabama at BirminghamORCID 0000-0002-8446-0084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jessy S. DeshaneiD· 2 shared Kayla F. GoliwasiD· 2 shared Mohammad AthariD· 2 shared A Hassan D I Pritchard· 1 shared Aakash P. DesaiiD· 1 shared Balu K. ChackoiD· 1 shared Benjamin WeiiD· 1 shared Diptiman ChandaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Jessy S. DeshaneORCID

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2 papers

Recent·Most cited

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

Kenneth P. Hough, Jennifer L. Trevor, Shaheer Ahmad, Yong Wang, Balu K. Chacko, Kayla F. Goliwas, John G. Strenkowski, Yuelong Liu, Joanna I. Nowak, Eugene Becker, Young-il Kim, Renita Holmes, Nathaniel B. Bone, Shia Vang, A Hassan D I Pritchard, , Jessy S. Deshane

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

Nature Communications · May 26, 2026Peer-reviewedImmunology

Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy

Kayla F. Goliwas, Kenneth P. Hough, Sruti Sivan, Sierra L. Single, Sameer S. Deshmukh, Joel L. Berry, Maya Khalil, Benjamin Wei, Yanis Boumber, Mohammad Athar, Aakash P. Desai, Selvarangan Ponnazhagan, James Donahue, Jessy S. Deshane

The paper develops a 3D lung tumor model to evaluate immunotherapy response and identifies biomarkers for predicting immune checkpoint inhibitor efficacy in NSCLC.

bioRxiv · May 19, 2025 · PreprintCancer Biology