Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery.
Sarah D. Davey, Josephine Forde-Thomas, Benjamin J. Hulme, Kristin Lees, Alice H. Costain, Mary Evans, Gabriel Rinaldi, Laura Frame, Laste Stojanovski, Frederick R. C. Simeons, Amy Tavendale, A. Kenneth MacLeod, Rémi Pichon, Yi‐Hsuan Lee, Oktawia Polak, , Karl F. Hoffmann
A cytochrome P450 humanised mouse model is used to study Schistosoma mansoni development, schistosomiasis, drug metabolism and drug efficacy.
bioRxiv · Nov 27, 2025 · PreprintPharmacology & Toxicology