Anionic lipid catalyzes the generation of cytotoxic insulin oligomers
Jhinuk Saha, Audrey Wolszczak, Navneet Kaur, Malitha C. Dickwella Widanage, Samuel D. McCalpin, Riqiang Fu, Jamel Ali, Ayyalusamy Ramamoorthy
This study shows that anionic lipids like DMPG influence insulin aggregation pathways and intermediate formation, with soluble intermediates being more cytotoxic than fibrils.
Biomolecules · Jul 11, 2025Peer-reviewedBiophysics