GABA-independent activation of GABAB receptor by mechanical forces
Yujia Huo, Yiwei Zhou, Lin Li, Fan Yang, Jiyong Meng, Feiteng He, Fengfan Zhang, Mengdan Song, Cangsong Shen, Yuxuan Liu, Philippe Rondard, Chanjuan Xu, X.Z. Shawn Xu, Jianfeng Liu
This paper shows that GABAB receptors can be activated by mechanical forces without GABA, through integrin-GB1 interactions leading to receptor activation and astrocyte remodeling.
Nature Communications · Nov 7, 2025Peer-reviewedNeuroscience