Jianfeng Liu

Chronic potentiation of metabotropic glutamate receptor 2 with a nanobody accelerates amyloidogenesis in Alzheimer's disease.

This study shows that chronic activation of mGlu2 receptors with a nanobody accelerates amyloid formation and worsens memory deficits in Alzheimer's disease models.

Structural Basis of Asymmetric Class C GPCR activation and distinct Gq coupling induced by force stimulation

This paper reveals how mechanical force activates mGlu2 through a unique cis mechanism and induces distinct Gq coupling, providing structural insights and a chemical toolset for modulating mechanosensitive GPCRs.

GABA-independent activation of GABAB receptor by mechanical forces

This paper shows that GABAB receptors can be activated by mechanical forces without GABA, through integrin-GB1 interactions leading to receptor activation and astrocyte remodeling.

TIP-seq: A Single-cell Multiomics Approach for Simultaneous Transcriptome and Intracellular Protein Profiling

TIP-seq enables simultaneous transcriptome and protein profiling in single cells, revealing immune checkpoint interactions and tumor microenvironment dynamics in NSCLC.

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in Caenorhabditis elegans

This study identifies two neuroendocrine circuits in C. elegans where nervous system signaling to the gut bidirectionally regulates lifespan depending on life stage.

Molecular insights into the atypical activation mechanism of GPR156 in maintaining auditory function

This study reveals the constitutive activity and dimerization mechanism of GPR156, explaining its role in auditory function through cryo-EM structures and functional analysis.

A C. elegans neuron both promotes and suppresses motor behavior to fine tune motor output

The paper shows that the C. elegans neuron RIM both promotes and suppresses locomotion behavior to fine tune motor output through dual neurotransmission mechanisms.

AI-driven high-throughput automation of behavioral analysis and dual-channel wireless optogenetics for multiplexing brain dynamics

This paper develops a wireless platform combining AI for high-throughput behavioral analysis with dual-channel optogenetics to study brain dynamics in freely behaving rats.

BBSome regulation of LITE-1 receptor in a cilium-independent manner in C. elegans

The paper identifies a cilium-independent function of BBSome in regulating the stability of the non-ciliary LITE-1 receptor in C. elegans ASH neurons.

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

The paper presents cryo-EM structures of the GABAB receptor in inactive and active states, revealing structural changes and Gi1 coupling mechanisms.