Author

Kyle R. Puhger

University of California, DavisORCID 0000-0002-3023-628XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:statistical model· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Brian Joseph WiltgeniD· 2 shared Jacob H. WilmotiD· 2 shared Ali SaadatiD· 1 shared Ana Paula CrestaniiD· 1 shared Cassiano R.A.F. DiniziD· 1 shared Hassan HassaniD· 1 shared Jacob RoshgadoliD· 1 shared Jamie N. KruegeriD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Brian Joseph WiltgenORCID

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3 papers

Recent·Most cited

Life as a Function: Why Transformer Architectures Struggle to Gain Genome-Level Foundational Capabilities

Hassan Hassan, Kyle R. Puhger, Ali Saadat, Johannes U. Mayer, Maximilian Sprang

This study shows that transformer models struggle to capture DNA's functional complexity, suggesting inherent limitations that scale cannot overcome.

bioRxiv · Jan 13, 2025 · PreprintSynthetic Biology

Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus

Jacob H. Wilmot, Cassiano R.A.F. Diniz, Ana Paula Crestani, Kyle R. Puhger, Jacob Roshgadol, Lin Tian, Brian Joseph Wiltgen

This study shows that phasic locus coeruleus activity enhances trace fear conditioning by increasing hippocampal dopamine release, which is critical for memory formation.

eLife · Oct 23, 2023Peer-reviewedNeuroscience

Recently formed context fear memories can be retrieved without the hippocampus

Jamie N. Krueger, Jacob H. Wilmot, Yusuke Teratani-Ota, Kyle R. Puhger, Sonya E. Nemes, Marrisa M. Lafreniere, Brian Joseph Wiltgen

The paper investigates whether dorsal hippocampus inactivation impairs retrieval of new context fear memories, finding that ChR2 stimulation impairs retrieval while DREADD activation does not.

bioRxiv · Nov 18, 2019 · PreprintNeuroscience