Author

Lasse Nygaard

University of CopenhagenORCID 0000-0002-3029-8982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Amelie SteiniD· 1 shared Cecilie L. SøltoftiD· 1 shared Kresten Lindorff‐LarseniD· 1 shared Lene ClauseniD· 1 shared Martin Grønbæk-ThygeseniD· 1 shared Michael LisbyiD· 1 shared Rasmus Hartmann‐PeterseniD· 1 shared Sofie Vincents NielseniD· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Amelie SteinORCID

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Author profile →

1 paper

Recent·Most cited

Folliculin variants linked to Birt-Hogg-Dube syndrome are targeted for proteasomal degradation

Lene Clausen, Amelie Stein, Martin Grønbæk-Thygesen, Lasse Nygaard, Cecilie L. Søltoft, Sofie Vincents Nielsen, Michael Lisby, Tommer Ravid, Kresten Lindorff‐Larsen, Rasmus Hartmann‐Petersen

The paper shows that BHD-linked FLCN variants cause loss of function via proteasomal degradation and misfolding, with potential therapeutic implications for stabilization.

PLoS Genetics · Nov 2, 2020Peer-reviewedMolecular Biology