Author

Cecilie L. Søltoft

University of CopenhagenORCID 0000-0002-3194-0287Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Adrienne W. PatoniD· 1 shared Amelie SteiniD· 1 shared Ana Paula Cordeiro· 1 shared Brian ChristenseniD· 1 shared Carsten ScaveniusiD· 1 shared Celeste Menuet HackneyiD· 1 shared Esben Skipper SørenseniD· 1 shared James C. PatoniD· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Adrienne W. PatonORCID

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2 papers

Recent·Most cited

Molecular BiologyPLoS GeneticsPeer-reviewedNov 2, 2020

Folliculin variants linked to Birt-Hogg-Dube syndrome are targeted for proteasomal degradation

Lene Clausen, Amelie Stein, Martin Grønbæk-Thygesen…·Rasmus Hartmann‐Petersen

The paper shows that BHD-linked FLCN variants cause loss of function via proteasomal degradation and misfolding, with potential therapeutic implications for stabilization.

33 citations

humanproteomics

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Molecular BiologybioRxivPreprintApr 11, 2017

Intermolecular Disulfide-Bond Formation In Human FICD Modulates The Activity Of The Hyperactive E234G Mutant

Raffaella Magnoni, Minttu S. Virolainen, Celeste Menuet Hackney…·Lars Ellgaard

This paper shows that FICD's adenylyltransferase activity induces ER stress and that its disulfide-bond formation modulates its activity in the context of a hyperactive mutant.

DOI 10.1101/126516

humanexperimental assay

𝕏 PostBluesky