Pascale Chavis

Automated pup-level analysis reveals distinct effects of prenatal CBD and THC exposure on maternal retrieval

This study uses automated analysis to show that prenatal CBD and THC exposure leads to distinct effects on maternal retrieval behavior in mice, with compound-specific changes in kinematics and learning.

Prenatal Cannabidiol and Δ9-Tetrahydrocannabinol exposure lead to sex-specific disruptions in risk assessment and behavioral switching via divergent rewiring of the adult mPFC

This study examines sex-specific effects of prenatal CBD and THC exposure on adult mouse behavior and prefrontal cortex circuitry, revealing distinct synaptic and behavioral outcomes.

Compound and sex specific medial prefrontal cortex rewiring after prenatal THC and CBD exposure

This study examines how prenatal exposure to THC and CBD affects medial prefrontal cortex circuitry in adult mice, revealing compound- and sex-specific changes in excitability and synaptic plasticity.

Prenatal Cannabinoids Produce Sex Specific Changes in Risk Assessment and Shared Increases in Repetitive Behavior in Adult Offspring

This study shows prenatal exposure to CBD or THC alters adult offspring behavior differently by sex, with CBD increasing female risk assessment and both increasing repetitive behavior.

Sex-specific disruptions in the developmental trajectory of anxiety due to prenatal cannabidiol exposure

This study shows prenatal CBD exposure causes sex-specific anxiety disruptions in mice, with females showing persistent anxiety-like behaviors and altered reward responsiveness.

Gestational CBD shapes insular cortex in adulthood

This study examines how prenatal CBD exposure affects the insular cortex in adult mice, revealing sex- and territory-specific disruptions in neuronal properties.

Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex

This study examines sex differences in synaptic properties and neuronal characteristics across subregions of the mouse insular cortex, revealing distinct features in excitability, synaptic strength, and plasticity.

Cell-Specific Disruptions in the Basolateral Amygdala-Accumbens Pathway of Fragile X Mice

This study investigates synaptic dysfunction in the BLA-NAcC pathway of FXS mice, finding increased synaptic strength and altered plasticity in specific SPN subtypes.

In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

The paper examines how in utero CBD exposure affects early-life behaviors in mice, finding sex-specific changes in weight, homing behavior, and vocalizations.

Dichotomous Intrinsic Properties of Adult Accumbens Medium Spiny Neurons Vanish in the Fragile X Mouse Model of Autism

The paper compares intrinsic properties of D1- and D2-MSNs in FXS mice and finds they lose their distinct characteristics, leading to a uniform phenotype.

Sex-specific divergent maturational trajectories in the post-natal rat basolateral amygdala

This study identifies sex-specific differences in the maturation of BLA neurons and synaptic properties in rats during adolescence and adulthood.

SEX-SPECIFIC TRAJECTORIES OF REELIN-DEPENDENT MATURATION OF DEEP LAYER PREFRONTAL NEURONS

This study investigates how reelin affects the sex-specific maturation of prefrontal cortex neurons and synaptic plasticity in mice.

Cannabinoid during adolescence phenocopies reelin haploinsufficiency in prefrontal cortex synapses

This study shows that adolescent cannabinoid exposure reduces prefrontal reelin expression and impairs synaptic plasticity, mimicking reelin haploinsufficiency.