Malnourishment and expanded microbiome maintain superior efficacy of the recombinant tuberculosis vaccine BCG::ESAT-6-PE25SS
Munish Puri, Manoharan Kumar, Nagaraja Haleagrahara, Harindra Sahkumara, Serrin Rowarth, Kylie Robertson, Selvakumar Subbian, Jeffrey Warner, C. M. Rush, Roland Ruscher, Matthew A. Field, Andreas Kupz
This study shows that malnourishment and microbiome changes enhance the efficacy of a recombinant BCG TB vaccine in mice, linking diet, microbiota, and immune responses to TB protection.
bioRxiv · Aug 19, 2026 · PreprintMicrobiology