Author

Roland Ruscher

Australian Institute of Tropical Health and MedicineORCID 0000-0002-8600-6985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andreas KupziD· 2 shared Matthew A. FieldiD· 2 shared Paul GiacominiD· 2 shared Alex C. LoukasiD· 1 shared C. M. RushiD· 1 shared Darren M. CrayniD· 1 shared David T. R. WilsoniD· 1 shared Denise L. DoolaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

Andreas KupzORCID

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3 papers

Recent·Most cited

Plant Molecules Protect Against Inflammatory Bowel Disease by Restoring Gut Microbiota-Immune Homeostasis and Suppressing Pro-inflammatory Markers

Karma Yeshi, Subir Sarker, Md Zohorul Islam, Darren M. Crayn, Stephen G. Pyne, Paul Giacomin, Matthew A. Field, Md. Mizanur Rahaman, David T. R. Wilson, Michael J. Smout, Norelle L. Daly, Alex C. Loukas, Roland Ruscher, Phurpa Wangchuk

This study identifies Garcinia brassii metabolites that reduce inflammation and restore gut microbiota balance in IBD, with garcinia biflavonoid 1 and parvifoliol F showing therapeutic potential.

bioRxiv · Aug 25, 2026 · PreprintImmunology

Malnourishment and expanded microbiome maintain superior efficacy of the recombinant tuberculosis vaccine BCG::ESAT-6-PE25SS

Munish Puri, Manoharan Kumar, Nagaraja Haleagrahara, Harindra Sahkumara, Serrin Rowarth, Kylie Robertson, Selvakumar Subbian, Jeffrey Warner, C. M. Rush, Roland Ruscher, Matthew A. Field, Andreas Kupz

This study shows that malnourishment and microbiome changes enhance the efficacy of a recombinant BCG TB vaccine in mice, linking diet, microbiota, and immune responses to TB protection.

bioRxiv · Aug 19, 2026 · PreprintMicrobiology

Lung epithelial progenitor-mediated release of TGF-β regulates induction and persistence of lung CD8+ TRM cells following mucosal BCG vaccination

Judith A. Blake, Julia Seifert, Socorro Miranda‐Hernandez, Roland Ruscher, Paul Giacomin, Denise L. Doolan, Andreas Kupz

This study shows that mucosal BCG vaccination induces lung CD8+ TRM cells via TGF-β activation by airway epithelial progenitors, linking tissue repair to immune memory.

Mucosal Immunology · May 30, 2025Peer-reviewedImmunology