Chun Liang

This study identifies locus-specific dysregulation of repetitive elements across 12 TCGA cancer types, linking their expression and methylation to biological functions and potential therapeutic targets.

The paper introduces CircCNNs, a CNN framework that identifies back splicing motifs in circRNA biogenesis with high specificity and reduced false positives.

The paper investigates the role of miR-26 in lens development and finds that its deficiency leads to adult-onset cataract through transcriptome alterations.

The paper shows hybridization in maize triggers global changes in trans-chromosomal methylation and demethylation, which can be maintained in subsequent generations, independent of Mop1 function.

This study identifies FGF2-driven gene expression changes in embryonic chicken RPE reprogramming, highlighting MAPK signaling and EMT processes.

This study identifies DNA demethylation as a key driver of chick retina regeneration through RPE reprogramming, with TET3 playing a critical role in this process.

CRISPR-DT designs gRNAs for the CRISPR-Cpf1 system using a machine learning model to improve target efficiency and specificity.

CRISPR-RT is a web service for designing CRISPR-C2c2 crRNA with improved target specificity, supporting multiple model organisms.