Georgios Tsissios

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

This study identifies species-specific oxygen sensing as a key factor in limb regeneration, showing that reducing oxygen sensing in amphibians enhances regenerative capacity while mammals require oxygen-sensitive pathways.

Specialized signaling centers direct cell fate and spatial organization in a limb organoid model

The paper develops a limb organoid model to study how signaling centers direct cell fate and spatial organization during limb development.

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression

Spotiflow improves spot detection in microscopy images using deep learning, achieving subpixel accuracy and efficiency across diverse datasets.

Macrophages modulate fibrosis during newt lens regeneration

This study shows that macrophages are essential for lens regeneration in newts by reducing fibrosis, modulating inflammation, and balancing cell proliferation and apoptosis.

Multi-species atlas resolves an axolotl limb development and regeneration paradox

The paper uses a multi-species single-cell atlas to resolve whether axolotls regenerate limbs by re-forming AER cells, finding they do not fully re-form AER but use a novel mesoderm-based program.

Regenerative hallmarks of aging: Insights through the lens of Pleurodeles waltl

This study examines age-related changes in lens regeneration in newts, finding that while regenerative capacity persists, aging slows the regeneration kinetics due to delayed cell cycle re-entry and ECM clearance.