Author

Juan Rodrigo Patiño-Mercau

Beth Israel Deaconess Medical CenterORCID 0000-0002-4989-5613Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Abigail R. EdwardsiD· 1 shared Alessandra Perfetto· 1 shared Alexander K. Ebralidze· 1 shared Angela Di BaldassarreiD· 1 shared Annalisa Di RuscioiD· 1 shared Barbara GhinassiiD· 1 shared CM Lam· 1 shared Daniel Geoffrey TeneniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abigail R. EdwardsORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 25, 2026

Myc inhibition triggers GM-CSF-driven regression of pancreatic tumours

Tania Campos, Roderik M. Kortlever, Nicole M. Sodir…·GI EVAN

This study shows that inhibiting Myc in pancreatic tumours triggers GM-CSF release, which drives tumour regression via cDC1s, offering a new therapeutic strategy for PDAC.

1 citation

mouseexperimental assay

Molecular BiologybioRxivPreprintSep 29, 2025

Small activating RNA AW1-51 (CEBPA-51) elicits targeted DNA demethylation to promote gene activation

Giulia Gaggi, Juan Rodrigo Patiño-Mercau, Marta Borchiellini…·Annalisa Di Ruscio

This study identifies the mechanism by which AW1-51, a small activating RNA, promotes DNA demethylation and reactivation of the CEBPA gene in cancer.

3 citations

humanDNA methylation