Developmental BiologyProceedings of the National Academy of SciencesPeer-reviewed
Frequent loss-of-heterozygosity in CRISPR-Cas9-edited early human embryos
Gregorio Alanis‐Lobato, Jasmin Zohren, Afshan McCarthy…·Kathy K. Niakan
The paper analyzes single-cell genomics and transcriptomics data from CRISPR-Cas9-edited human embryos to assess unintended editing outcomes and loss-of-heterozygosity.