Gregorio Alanis‐Lobato

Marsupial single-cell transcriptomics provides an atlas of developmental heterochrony

This study generates the first single-cell transcriptomic atlas of marsupial gastrulation and early organogenesis, revealing accelerated transcriptional programs and novel tissues associated with developmental heterochrony.

MICA: A multi-omics method to predict gene regulatory networks in early human embryos

The paper evaluates gene regulatory network prediction methods in early human embryos, finding that MICA, combining mutual information with chromatin accessibility, provides more reproducible and biologically meaningful results.

Role of Yap1 in adult neural stem cell activation

This study identifies Yap1 as a regulator of adult neural stem cell activation, showing that its gain-of-function mutant promotes cell cycle entry and aberrant differentiation while wild-type Yap1 does not.

Frequent loss-of-heterozygosity in CRISPR-Cas9-edited early human embryos

The paper analyzes single-cell genomics and transcriptomics data from CRISPR-Cas9-edited human embryos to assess unintended editing outcomes and loss-of-heterozygosity.

The latent geometry of the human protein interaction network

This paper embeds the human protein interaction network in hyperbolic space to reveal latent geometric properties that correlate with biological features and predict protein interactions.

A reliable and unbiased human protein network with the disparity filter

The paper constructs a reliable and unbiased human protein network using a disparity filter to address biases in existing networks.