Clostridioides difficile major toxins remodel the intestinal epithelia, affecting spore adherence/internalization into intestinal tissue and their association with gut vitronectin.
Pablo Castro-Córdova, Osiris K. Lopez-Garcia, Josué Orozco, Nicolás Montes-Bravo, Fernando Gil, Marjorie Pizarro‐Guajardo, Daniel Paredes‐Sabja
This study shows that C. difficile toxins TcdA and TcdB remodel fibronectin and vitronectin in intestinal tissue, enhancing spore adherence and internalization, which may contribute to disease recurrence.
bioRxiv · Jan 29, 2025 · PreprintMicrobiology