StructGuy predicts functional effects of genetic variants using a data leakage-free supervised approach, achieving competitive performance against zero-shot methods.

bioRxiv · Dec 2, 2025 · PreprintBioinformatics

Regulation of the transcriptome, miRNAs, and alternative splicing in a FSGS zebrafish injury model

Francescapaola Mattias, Olga V. Tsoy, Anna Iervolino, Stefan Simm, Elke Hammer, Alexander Greß, Tim Lange, Florian Siegerist, Sabine Ameling, Tim Kacprowski, Markus List, Olga V. Kalinina, Sören Franzenburg, Giovambattista Capasso, Karlhans Endlich, , Felix Kliewe

This study investigates alternative splicing and miRNA regulation in a zebrafish FSGS model, identifying key splicing events and miRNAs associated with disease progression.

bioRxiv · Jul 9, 2025 · PreprintCell Biology

Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension

Francescapaola Mattias, Olga V. Tsoy, Elke Hammer, Alexander Greß, Stefan Simm, Chit Tong Lio, Sabine Ameling, Kerstin Amann, Leonie Dreher, Ulrich Otto Wenzel, Tim Kacprowski, Markus List, Olga V. Kalinina, Karlhans Endlich, Jan Baumbach, , Felix Kliewe

The paper investigates alternative splicing in mechanically stretched podocytes, identifying splicing events in Shroom3 and Myl6 that may contribute to hypertensive nephropathy.

Journal of the American Society of Nephrology · May 26, 2025Peer-reviewedCell Biology

An extended catalogue of tandem alternative splice sites in human tissue transcriptomes

Andrey A. Mironov, Stepan Denisov, Alexander Greß, Olga V. Kalinina, Dmitri Davidovich Pervouchine

The paper presents an extended catalogue of tandem alternative splice sites in human tissues, analyzing their expression and regulation.

PLoS Computational Biology · Apr 7, 2021Peer-reviewedBioinformatics