Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Liora S. Katz, Emira J. Visser, Kathrin Plitzko, Marloes A. M. Pennings, Peter J. Cossar, Isabelle Tse, Markus Kaiser, Luc Brunsveld, Christian Ottmann, Donald K. Scott
This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.
Nature Communications · Mar 2, 2025Peer-reviewedCell Biology