Luc Brunsveld

Modulation of the 14-3-3σ/C-RAF autoinhibited complexby molecular glues

This paper designs molecular glues that stabilize the 14-3-3/C-RAF autoinhibited complex, showing selectivity and functional effects in biophysical and cell assays.

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design

This paper develops a molecular glue-based PROTAC (MGPROTACs) to ubiquitinate the 14-3-3/Estrogen Receptor complex, demonstrating cooperative complex formation and selective ubiquitination through linker design.

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

Crosstalk interactions between transcription factors ERRalpha and PPARalpha assist PPARalpha-mediated gene expression

The paper identifies crosstalk between ERRalpha and PPARalpha transcription factors, showing ERRalpha can act as both a repressor and activator of PPARalpha-mediated gene expression.

A DNA-based synthetic apoptosome

This paper describes a DNA-based synthetic apoptosome that demonstrates proximity-driven enzymatic activity and provides insights into caspase-9 regulation.