Author

Peter J. Cossar

Eindhoven University of TechnologyORCID 0000-0002-8260-5710Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Christian OttmanniD· 3 shared Luc BrunsveldiD· 3 shared Emira J. VisseriD· 2 shared Aitana de la Cuadra BastéiD· 1 shared Alessio CiulliiD· 1 shared Bente A. SomseniD· 1 shared Carlo J. A. VerhoefiD· 1 shared Charlotte CroweiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

Christian OttmannORCID

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintNov 17, 2025

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design

Carlo J. A. Verhoef, Charlotte Crowe, Mark A. Nakasone…·Peter J. Cossar

This paper develops a molecular glue-based PROTAC (MGPROTACs) to ubiquitinate the 14-3-3/Estrogen Receptor complex, demonstrating cooperative complex formation and selective ubiquitination through linker design.

DOI 10.1101/2025.11.17.688825

protein structuredeep learning

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Cell BiologyNature CommunicationsPeer-reviewedMar 2, 2025

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

Liora S. Katz, Emira J. Visser, Kathrin Plitzko…·Donald K. Scott

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

32 citationstop 2%

humanexperimental assay

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Cancer BiologybioRxivPreprintApr 25, 2024

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

Emira J. Visser, Maria Donaldson Collier, Joseph C. Siefert…·Luc Brunsveld

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

6 citations

humanproteomics

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