Christian Ottmann

This paper designs molecular glues that stabilize the 14-3-3/C-RAF autoinhibited complex, showing selectivity and functional effects in biophysical and cell assays.

This paper develops a molecular glue-based PROTAC (MGPROTACs) to ubiquitinate the 14-3-3/Estrogen Receptor complex, demonstrating cooperative complex formation and selective ubiquitination through linker design.

This study shows that 14-3-3ζ binding to phosphorylated Tau reduces its association with microtubules and inhibits aggregation and condensation.

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.