Author

Manoj Kumar Sriramoju

Institute of Biological Chemistry, Academia SinicaORCID 0000-0002-7244-0780Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

Shang‐Te Danny HsuiD· 2 shared Carlo CamilloniiD· 1 shared Chih-Hsuan LaiiD· 1 shared Chittaranjan DasiD· 1 shared Cristina PaissoniiD· 1 shared Dabin Jung· 1 shared Daniel Patrick FlahertyiD· 1 shared Elizaveta I. ShestoperovaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Shang‐Te Danny HsuORCID

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2 papers

Recent·Most cited

Substrate biasing in UCHL5 proteoforms

Rishi S. Patel, Nipuni M. Pannala, Chih-Hsuan Lai, Manoj Kumar Sriramoju, Yongsheng Wang, Ting Cheng, Dabin Jung, Payam Kelich, Soroush Asadi, Elizaveta I. Shestoperova, Shalini Iyer, Emad Tajkhorshid, Daniel Patrick Flaherty, Eric R. Strieter, Shang‐Te Danny Hsu, Chittaranjan Das

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

A conformational fingerprint for amyloidogenic light chains.

Cristina Paissoni, Sarita Puri, Luca Broggini, Manoj Kumar Sriramoju, Martina Maritan, Rosaria Russo, Valentina Speranzini, Federico Ballabio, Mario Nuvolone, Giampaolo Merlini, Giovanni O. Palladini, Shang‐Te Danny Hsu, Stéfano Ricagno, Carlo Camilloni

This study identifies a conformational fingerprint distinguishing AL from MM light chains using SAXS and MD simulations, revealing a unique H state in AL LCs.

bioRxiv · Jul 12, 2024Biophysics