Author

Valentina Speranzini

European Molecular Biology LaboratoryORCID 0000-0002-7219-3097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. PflugiD· 1 shared Anna DubánkováiD· 1 shared Carlo CamilloniiD· 1 shared Chris MeieriD· 1 shared Cristina PaissoniiD· 1 shared Elisa DonatiiD· 1 shared Federico BallabioiD· 1 shared Giampaolo MerliniiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

A. PflugORCID

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2 papers

Recent·Most cited

A conformational fingerprint for amyloidogenic light chains.

Cristina Paissoni, Sarita Puri, Luca Broggini, Manoj Kumar Sriramoju, Martina Maritan, Rosaria Russo, Valentina Speranzini, Federico Ballabio, Mario Nuvolone, Giampaolo Merlini, Giovanni O. Palladini, Shang‐Te Danny Hsu, Stéfano Ricagno, Carlo Camilloni

This study identifies a conformational fingerprint distinguishing AL from MM light chains using SAXS and MD simulations, revealing a unique H state in AL LCs.

bioRxiv · Jul 12, 2024Biophysics

Backtracking of influenza polymerase upon consecutive incorporation of nucleoside analogue T1106 directly observed by high resolution cryo-electron microscopy

Tomáš Kouba, Anna Dubánková, Petra Drncová, Elisa Donati, Pietro Vidossich, Valentina Speranzini, A. Pflug, Johanna Huchting, Chris Meier, Marco De Vivo, S. Cusack

This study uses cryo-EM to observe how influenza polymerase backtracks after incorporating T1106-MP nucleotides, revealing structural changes that lead to chain termination.

bioRxiv · Jun 10, 2022 · PreprintMolecular Biology