Author

Ruth Helmus Nissly

Pennsylvania State UniversityORCID 0000-0002-3102-7447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Suresh Varma KuchipudiiD· 4 shared Abhinay GontuiD· 3 shared Lindsey Cecelia LaBellaiD· 2 shared Meera Surendran NairiD· 2 shared Padmaja JakkaiD· 2 shared Santhamani RamasamyiD· 2 shared Shubhada K. ChotheiD· 2 shared Sougat MisraiD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMicrobiology

Suresh Varma KuchipudiORCID

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4 papers

Recent·Most cited

Comparative analysis of serological assays and sero-surveillance for SARS-CoV-2 exposure in US cattle

Santhamani Ramasamy, Meysoon Quraishi, Swastidipa Mukherjee, Sonalika Mahajan, Lindsey Cecelia LaBella, Shubhada K. Chothe, Padmaja Jakka, Abhinay Gontu, Sougat Misra, Meera Surendran Nair, Ruth Helmus Nissly, Suresh Varma Kuchipudi

This study evaluates serological assays for SARS-CoV-2 in US cattle, finding no evidence of natural infection or transmission and highlighting issues with false positives in neutralization assays.

Microorganisms · Mar 5, 2025Peer-reviewedMicrobiology

A trans-amplifying mRNA vaccine with consensus spike elicits broadly cross-neutralizing antibody response against multiple SARS-CoV-2 variants

Abhinay Gontu, Sougat Misra, Shubhada K. Chothe, Santhamani Ramasamy, Padmaja Jakka, Maurice Byukusenge, Lindsey Cecelia LaBella, Meera Surendran Nair, Bhushan M. Jayarao, Marco Archetti, Ruth Helmus Nissly, Suresh Varma Kuchipudi

This study evaluates a trans-amplifying mRNA vaccine with a consensus spike protein, showing it elicits broad cross-neutralizing antibodies against multiple SARS-CoV-2 variants with reduced antigen dose.

bioRxiv · Jan 22, 2025 · PreprintMicrobiology

Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality

Jule Goike, Ching‐Lin Hsieh, Andrew P. Horton, Elizabeth C. Gardner, Foteini Bartzoka, Nianshuang Wang, Kamyab Javanmardi, Andrew S. Herbert, Shawn A. Abbasi, Rebecca L. Renberg, Michael J. Johanson, José Cardona, Thomas H. Segall-Shapiro, Ling Zhou, Ruth Helmus Nissly, , Jimmy Gollihar

The paper identifies SARS-CoV-2 neutralizing antibodies from convalescent patients and describes a novel quaternary binding mechanism using high-throughput methods.

bioRxiv · Apr 7, 2021 · PreprintSynthetic Biology

Continued circulation, recombination and evolution of the ancient subcontinent lineage despite predominance of the recent arctic-like lineage rabies viruses (RABV) in India

Jagadeeswaran Deventhiran, Bhuvaneswari Srinivasan, Manoharan Seeralan, Vijayarani Kanagaraj, Sangeetha Raju, Kumanan Kathaperumal, Ruth Nissly, Sunitha Manjari Kasibhatla, Mohan M Kale, Urmila Kulkarni-Kale, Suresh V Kuchipudi

This study analyzes rabies virus genetic diversity and evolution in southern India, finding co-circulation of ancient subcontinent and recent arctic-like lineages with recombination and higher evolutionary rates.

bioRxiv · Aug 22, 2018 · PreprintMicrobiology