Elizabeth C. Gardner

This study evolves a T7 RNA polymerase variant with a capping enzyme to enable efficient gene expression in eukaryotes, showing improved performance in yeast and mammalian cells.

The paper develops yeast biosensors for CB1R and CB2R to screen cannabinoids and identify structure-activity relationships.

This study engineers yeast to produce cholesterol, enabling functional expression of human opioid and other GPCRs, creating biosensors with measurable agonist responses and antagonist inhibition.

The paper designs synthetic promoters and CRISPR-based transcription factors to enable orthogonal gene expression control in plants, demonstrating a fully artificial Orthogonal Control System (OCS).

The paper identifies SARS-CoV-2 neutralizing antibodies from convalescent patients and describes a novel quaternary binding mechanism using high-throughput methods.