Author

Steven He

UNSW SydneyORCID 0000-0002-3113-9588Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Antoine de WeckiD· 2 shared Mohamed FarehiD· 2 shared Paul G. EkertiD· 2 shared Wenxin HuiD· 2 shared Alice SalibiD· 1 shared Carolyn ShembreyiD· 1 shared Chelsea MayohiD· 1 shared Deborah L. WhiteiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Antoine de WeckORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

METTL1 gene dosage and catalytic activity define a targetable vulnerability in pediatric cancers

Pei Yan Liu, Steven He, Olesya O. Panasenko, Fedor L. Bezrukov, Alice Salib, Priyank Rawat, Wenxin Hu, Chelsea Mayoh, Marie Wong, Zara A. Barger, Emmy D.G. Fleuren, Greg M. Arndt, Ian P. Street, Mohamed Fareh, Antoine de Weck, Paul G. Ekert

This study identifies METTL1 gene dosage and catalytic activity as therapeutic targets in pediatric cancers, showing that inhibiting METTL1 synergizes with BCL-xL inhibitors.

bioRxiv · Oct 21, 2026 · PreprintCancer Biology

Systematic silencing of oncogenic fusion transcripts with ultra-precise CRISPR-Cas13b

Wenxin Hu, Honglin Chen, Joshua M. L. Casan, Carolyn Shembrey, Steven He, Lauren M. Brown, Timothy P. Hughes, Deborah L. White, Antoine de Weck, Ilia Voskoboinik, Joseph A. Trapani, Paul G. Ekert, Teresa Sadras, Mohamed Fareh

This paper introduces CRISPR-PspCas13b as a method to systematically silence oncogenic fusion transcripts, showing effectiveness against drug-resistant cancer drivers.

bioRxiv · Feb 10, 2025 · PreprintMolecular Biology