METTL1 gene dosage and catalytic activity define a targetable vulnerability in pediatric cancers
Pei Yan Liu, Steven He, Olesya O. Panasenko, Fedor L. Bezrukov, Alice Salib, Priyank Rawat, Wenxin Hu, Chelsea Mayoh, Marie Wong, Zara A. Barger, Emmy D.G. Fleuren, Greg M. Arndt, Ian P. Street, Mohamed Fareh, Antoine de Weck, Paul G. Ekert
This study identifies METTL1 gene dosage and catalytic activity as therapeutic targets in pediatric cancers, showing that inhibiting METTL1 synergizes with BCL-xL inhibitors.
bioRxiv · Oct 21, 2026 · PreprintCancer Biology