Author

Leah E Simon

Cornell UniversityORCID 0000-0002-3129-019XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Paula E. CoheniD· 3 shared María de las Mercedes CarroiD· 2 shared Stephanie TanisiD· 2 shared Adriana K. AlexanderiD· 1 shared Alexis DziubekiD· 1 shared Amanda Touey-MayiD· 1 shared Andrew GrimsoniD· 1 shared Anna J. WoodiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

Paula E. CohenORCID

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3 papers

Recent·Most cited

Meiotic prophase I disruption as a strategy for non-hormonal male contraception using small-molecule inhibitor JQ1

Leah E Simon, Stephanie Tanis, Adriana K. Alexander, Tegan S. A. Horan, María de las Mercedes Carro, Samantha-Jane Bonnett, Roni Ben-Shlomo, Audrey Xie, Charles G. Danko, Jelena Lujić, Paula E. Cohen

This study shows that JQ1 disrupts meiotic prophase I in male mice, leading to reversible infertility, suggesting a potential non-hormonal contraceptive strategy.

bioRxiv · May 13, 2025 · PreprintCell Biology

Argonaute proteins regulate the timing of the spermatogenic transcriptional program

María de las Mercedes Carro, Alexis Dziubek, Amanda Touey-May, Elizabeth A. Popkowski, Mark Abdelmassih, Leah E Simon, Stephanie Tanis, Faraz Ahmed, Jennifer K. Grenier, Andrew Grimson, Paula E. Cohen

This study shows AGO3 and AGO4 regulate transcriptional silencing of XY-linked genes during meiosis in spermatogenesis, impacting fertility and sperm morphology.

bioRxiv · Dec 31, 2024 · PreprintDevelopmental Biology

CNTD1 plays crucial roles in prophase I progression and crossover designation during female meiosis and is critical for establishing the ovarian reserve

Anna J. Wood, Rania M. Ahmed, Leah E Simon, Rachel Bradley, Ian D. Wolff, Paula E. Cohen

This study identifies CNTD1's role in female meiosis, showing it is essential for crossover designation and ovarian reserve establishment through its interaction with MutLγ and regulation of CHK2.

bioRxiv · Sep 25, 2023 · PreprintGenetics