Ning Qing Liu

Rapid depletion of CTCF and cohesin proteins reveals dynamic features of chromosome architecture.

This study shows that cohesin accumulates at CTCF-bound loop anchors after WAPL depletion, and active genes form long-range clusters independent of cohesin.

Perturbations in 3D genome organization can promote acquired drug resistance

The paper shows that disrupting nuclear lamina association promotes ABCB1 gene derepression and taxol resistance in RPE cells.

Dynamic chromosomal interactions and control of heterochromatin positioning by Ki67

The paper investigates Ki67's role in chromatin organization by analyzing its genomic interactions and dynamics during the cell cycle in human cells.

CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

The paper investigates the role of CTCF and cohesin in LAD positioning, finding they reinforce borders but do not position LADs, and mediate fine-tuning of nuclear lamina interactions.

WAPL maintains dynamic cohesin to preserve lineage specific distal gene regulation

This study shows WAPL maintains dynamic cohesin at lineage-specific regulatory regions in mouse embryonic stem cells, which is essential for gene expression and pluripotency.