Hans Teunissen

Genome - nuclear lamina interactions are multivalent and cooperative

The paper investigates how genomic regions called LADs interact with the nuclear lamina, finding that these interactions are multivalent and cooperative, with some subregions having stronger affinity and influencing neighboring sequences.

Rapid depletion of CTCF and cohesin proteins reveals dynamic features of chromosome architecture.

This study shows that cohesin accumulates at CTCF-bound loop anchors after WAPL depletion, and active genes form long-range clusters independent of cohesin.

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF

This study shows ZNF143 regulates nuclear-encoded mitochondrial genes and is essential for development, without affecting chromatin looping or CTCF interactions.

Perturbations in 3D genome organization can promote acquired drug resistance

The paper shows that disrupting nuclear lamina association promotes ABCB1 gene derepression and taxol resistance in RPE cells.

Pioneer activity distinguishes activating from non-activating pluripotency transcription factor binding sites

The paper identifies that SOX2 maintains chromatin accessibility at regulatory sites that drive gene expression, distinguishing them from non-activating binding sites.

Dynamic chromosomal interactions and control of heterochromatin positioning by Ki67

The paper investigates Ki67's role in chromatin organization by analyzing its genomic interactions and dynamics during the cell cycle in human cells.

Unexpected gene activation following CRISPR-Cas9-mediated genome editing

This study reports that lentiviral-based CRISPR-Cas9 vectors can integrate into the target genomic location, unexpectedly activating the target gene.

Hi-C Analyses with GENOVA: a case study with cohesin variants

GENOVA is an R-package for analysing Hi-C data, demonstrating that cohesin subunits SA1 and SA2 differentially affect loop formation and genome compartmentalisation.

WAPL maintains dynamic cohesin to preserve lineage specific distal gene regulation

This study shows WAPL maintains dynamic cohesin at lineage-specific regulatory regions in mouse embryonic stem cells, which is essential for gene expression and pluripotency.

Condensin’s ATPase Machinery Drives and Dampens Mitotic Chromosome Condensation

This study shows that condensin complexes use opposing ATPase sites to drive and dampen chromosome condensation, with condensin II playing a key role in decatenation and axis formation.

Systematic identification of human SNPs affecting regulatory element activity

The paper identifies over 30,000 SNPs affecting regulatory element activity using SuRE reporter technology, linking them to gene regulation and potential human traits.

Locus-Specific Enhancer Hubs And Architectural Loop Collisions Uncovered From Single Allele DNA Topologies

The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.